Cat Vaccinations: What You Need to Know

Medically reviewed by Bartley Harrison, DVM
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Kitten Receiving Vaccination Cat Vaccination Feature

Vaccinations are an important part of keeping your cat safe and healthy. In this article, we will cover some common questions: what are vaccines, how do they work, which vaccines does your cat need, and what can you expect after your cat is vaccinated?

What Are Cat Vaccinations?

Vaccines (also called immunizations or shots) help prevent a cat from contracting contagious infectious diseases. Vaccines are made from viruses or bacteria that have been attenuated (modified to not cause disease) or killed so that they are safe to administer but still able to trigger an immune response.

Vaccines are injected underneath the cat’s skin or sometimes given intranasally (a liquid in the nose). The vaccines stimulate the cat’s immune system to mount a response against the disease-causing agents without causing illness since they contain only harmless or already killed particles.

Seeing these foreign particles will cause the immune system to produce antibodies against that virus or bacterial strain. If the cat is ever exposed to the disease in the future, production of these antibodies will increase dramatically and fight off the infection before it causes significant illness.

Vaccines are recommended for all cats and kittens, including both outdoor and indoor cats. In the United States, the American Association of Feline Practitioners (AAFP) oversees a Feline Vaccination Advisory Panel, which periodically reviews vaccination research and offers recommendations and guidelines for all cats.

The AAFP Feline Vaccination Advisory Panel last revised its vaccination guidelines for cats in 2020.

The Vaccinations Your Cat Needs

Although vaccinations are recommended for all cats and kittens, every cat does not necessarily need every vaccine available. Some vaccines are called “core” vaccines, meaning that they are recommended for all cats and kittens, regardless of whether they live indoors or outdoors.

Core Vaccines

Core vaccines include:

Fortunately, one combo vaccine (abbreviated FVRCP) covers rhinotracheitis, calicivirus, and panleukopenia. The FeLV vaccine is recommended for kittens since they are more susceptible to the disease than adult cats.

Other vaccines are considered “non-core,” meaning they are recommended for some cats, but other cats might not need them.

Non-Core Vaccines

Non-Core Vaccines Include:

Your veterinarian can tell you which non-core vaccines are recommended for your cat or kitten based on your cat’s lifestyle, age, exposure risk, and health status. Your veterinarian may not recommend continued FeLV vaccination after a year of age for an indoor-only cat that lives alone or has no FeLV-infected housemates.

It is important to note that, although a vaccine for feline immunodeficiency virus (FIV) was once available, its effectiveness was questionable and the vaccine is no longer produced or distributed in North America. Vaccination against FIV is no longer recommended by the AAFP.

Additionally, although a vaccine for feline infectious peritonitis (FIP) exists, the AAFP does not recommend vaccination for FIP. Vaccination against Bordetella bronchiseptica and Chlamydia felis is uncommon in cats. These vaccines are generally reserved for cats living in high-risk environments like shelters with a history of outbreaks of upper respiratory infections due to these bacteria.

What To Expect After Cat Vaccinations

After your cat receives vaccines, she might be a little sore at the injection site for a few days. The feeling is likely similar to what people feel after getting a flu vaccine.
It’s best to avoid touching your cat in the area where she was injected with the vaccine. Some cats are a little sleepy or lazy after getting shots, but this generally goes away on its own by the next day.

Cat Vaccination Side Effects

Side Effects of Cat Vaccinations

Cat vaccines, although extremely safe, do carry some risk of side effects. It’s good to familiarize yourself with the common side effects of cat vaccines so you can watch out for anything abnormal. These symptoms should be mild and last less than a day or two.

Some common minor side effects of cat vaccines include:

  • Discomfort at the injection site
  • Minor swelling (a lump) at the injection site
  • Low fever (a cat’s normal temperature ranges from 100.5 to 102.5 degrees Fahrenheit)
  • Lethargy (low energy)
  • No appetite
  • Runny nose, coughing or sneezing (after intranasal vaccines)

Sometimes cats experience a more serious adverse reaction to vaccinations.

A serious allergic reaction, called anaphylaxis, can cause severe, life-threatening symptoms. Anaphylactic reactions to vaccines are rare in cats, occurring in approximately 1 to 10 of every 10,0000 vaccines administered. Such reactions usually happen soon after the cat receives the vaccine.

If your cat develops any of the following symptoms within a few hours of getting vaccines, call your veterinarian or an emergency veterinary hospital:

  • Hives (raised bumps on the skin)
  • Facial swelling
  • Difficulty breathing
  • Vomiting
  • Diarrhea
  • Weakness
  • Collapse

If your cat experiences an allergic reaction to vaccines, it doesn’t necessarily mean they can never be vaccinated again. Your veterinarian will work with you to determine a plan for future vaccines. Such plans may include spacing vaccines out, administering a premedication before vaccines to prevent a reaction, or in some cases, not giving the vaccine again.

Another serious adverse vaccine reaction that is seen in cats is called feline injection-site sarcomas (FISS).

FISS are rare, occurring in approximately 1 out of every 10,000 to 30,000 vaccinations. FISS are cancerous tumors that develop at the injection site of vaccines, microchips, long-acting steroids, or other drugs. These tumors can occur just a few months after injection or up to 10 years later.

If your cat develops a lump at the site of the vaccine, tell your veterinarian right away. Most lumps go away on their own and do not go on to become FISS, but your veterinarian will want to keep a close eye on any lumps that pop up after your cat receives vaccines.

Frequently Asked Questions About Cat Vaccinations

What vaccines do indoor cats need?

All cats, whether they live indoors exclusively or go outside, need the core vaccines, which are panleukopenia (feline distemper), feline herpesvirus (viral rhinotracheitis or FHV-1), calicivirus and rabies. In addition to these shots, the FeLV vaccine is recommended for all cats less than a year old. Your veterinarian may also recommend certain non-core vaccines for your indoor cat depending on her health history and the health of any other pets living in the household.

Do cats need to be vaccinated every year?

How frequently your cat needs to be vaccinated depends on her age, lifestyle, and individual health risks. Kittens are vaccinated frequently at first (every three to four weeks starting at 6 to 8 weeks of age until they are 16 to 20 weeks old). After a kitten is done with her initial vaccination series, booster vaccines are required six months to one year later. Thereafter, adult cats need additional vaccines every one to three years, depending on the specific vaccine.

Some vaccines, like the rabies vaccine, have different recommended frequencies depending on the vaccine manufacturer and local laws. Some rabies vaccines are good for just one year and others are effective for three years. Consult with your veterinarian to find out how frequently your cat requires immunizations. Vaccines, however, are just one part of your cat's health care plan. Regardless of vaccine frequency, cats should have a physical exam from a vet every year.

When should cats be vaccinated?

Kittens should start their initial vaccines series at 6 to 8 weeks old. If kitten vaccinations are given before this age, maternal antibodies (which the kittens get from their mother’s milk, providing them with immunity) interfere with the vaccinations, rendering them ineffective.

How much does a vaccine for a cat cost?

The price for vaccines varies, depending on where you live and where you choose to get your cat vaccinated. At your veterinary hospital, you might pay anywhere from $15 to $28 per vaccine. If you combine your cat’s vaccines with her yearly physical exam, the cost is higher since you are paying the exam fee as well (this varies, but might range from $45 to $55).

You can save some money by taking your cat to a low-cost vaccine clinic, which might be offered by your veterinarian, a humane society in your town, or your local government. Vaccines at these shot clinics may be as low as $10 per vaccine, with no exam fee. However, it’s always a good idea to have your cat examined by a veterinarian before she gets vaccines because it’s not safe to give vaccines to a cat that is running a fever or otherwise sick.

About Jackie Brown

Jackie Brown is a freelance writer specializing in the pet industry. She writes on all pet and veterinary topics, including general health and care, nutrition, grooming, behavior, training, veterinary and health topics, rescue and animal welfare, lifestyle, and the human-animal bond. Jackie is the former editor of numerous pet magazines and is a regular contributor to pet magazines and websites.

One thought on “Cat Vaccinations: What You Need to Know

  1. Zoe Campos

    Thanks for warning me that my cat can feel a bit sore or off after getting her vaccine. We adopted our domestic short hair at three months, so I feel like she might be a bit overdue for her vaccines. Still, I hope that we can easily find a clinic that offers pet vaccinations immediately so she can get her shots as soon as possible.

    http://munsteranimal.com/

    Reply

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