Best Medication for Cat Allergies

The best medications for cat allergies are safe and effective, helping you to live comfortably around cats without drowsiness or other side effects.

That’s why we chose Allegra Allergy 24-Hour Gel Caps as the overall best medication for cat allergies. Made with fexofenadine, these gel caps provide long-lasting relief without drowsiness. The gel caps are easy to swallow and safe for anyone aged 12 and over.

While it’s appropriate for a wide range of people, this allergy medication isn’t right for everyone. To help you find the medication for you, we’ve also rounded up our recommendations for the best allergy medications for people on a budget, the best liquid medications, the best nasal spray, and more.

Before we jump into the reviews, let’s talk about the different types of medications for cat allergies and how we chose our top recommendations.

Quick Look: Medications for Cat Allergies


Best Antihistamine Gel Cap

Allegra Allergy 24 Hour Gelcaps
  • 24 hour protection
  • Fast-acting formula
  • Price: $21.72
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Runner Up

Zyrtec 24 Hour Allergy Relief Tablets
  • Effective
  • 24-hour allergy defense
  • Price: $24.97
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Best Budget Antihistamine Tablet

Basic Care Aller-Ease, Fexofenadine Hydrochloride Tablets
  • Significantly more affordable than the name brand alternative
  • Provides consistent allergy relief without side effects
  • Price: $15.99
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Best Nasal Steroid Spray

Nasacort Allergy 24 Hour (Triamcinolone)
  • Highly effective in managing nasal symptoms
  • Easy to administer
  • Price: $12.46
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Types of Medications for Cat Allergies


Antihistamines block histamine, which is a biochemical messenger that triggers the immune response we characterize as an allergic reaction.

Hate drowsiness and want to feel fresh? Choose new generation antihistamines.

Antihistamines were developed in the 1940s. Early antihistamines penetrated the blood-brain barrier to reach histamine receptors in the brain.

Older antihistamines are referred to as first-generation antihistamine drugs. The older that an antihistamine is, the greater the likelihood of drowsiness and other side effects. These antihistamines are still on the market today. Perhaps the best-known example is Benadryl or diphenhydramine.

In the 1980s, scientists developed the second generation of antihistamine drugs.
New antihistamines cross the blood-brain barrier to a lesser extent than do first-generation antihistamines. Consequently, they cause fewer side effects and are usually non-drowsy.

They’re usually longer-lasting, allowing you to dose once daily rather than once every few hours.
For most allergy sufferers, newly-developed antihistamines provide relief without side effects.

Types of First-Generation Antihistamine Medications for Cat Allergies:

  • Chlorpheniramine (ChlorTrimeton)
  • Diphenhydramine (Benadryl)
  • Promethazine (Phenergan)
  • Hydroxyzine (Vistaril)

Types of New-Generation Antihistamine Medications for Cat Allergies:

  • Loratidine (Claritin)
  • Cetirizine (Zyrtec)
  • Levocetirizine (Xyzal)
  • Fexofenadine (Aller-ease, Allegra)
  • Nasal Steroid Sprays

Not to be confused with the anabolic steroids your jacked-up brother-in-law probably uses, corticosteroids target inflammation to minimize allergy symptoms.

Nasal steroid sprays fight the stuffiness, itching, and runniness that make you and your nose miserable. Sensitive individuals may find that nasal steroids make their nose feel even worse. Side effects are rare, but they include nosebleeds and, ironically, runniness.

Types of Nasal Steroid Medications for Cat Allergies:

  • Budesonide (Rhinocort)
  • Fluticasone (Flonase)
  • Triamcinolone (Nasacort Allergy 24HR)
  • Decongestants

Decongestants shrink the blood vessels in your nose, promoting airflow and helping you breathe easier. This is great when you haven’t breathed through your nostrils all day, but it’s important to remember that with shrunken blood vessels comes increased blood pressure. If you already have high blood pressure, this could be a problem.

Decongestants pose a risk to those suffering from glaucoma, heart conditions, diabetes, and thyroid disease. In essence, decongestants can help you breathe, but they can also make other problems a lot worse.

Therefore, decongestants aren’t a good choice for most cat allergy sufferers.

Types of Decongestant Medications for Cat Allergies:

  • Pseudoephedrine (Sudafed)
  • Allegra-D
  • Claritin-D
  • Zyrtec-D

Watch out for medications that contain acetaminophen.

Acetaminophen, the active ingredient in Tylenol, is added to some allergy medications to relieve headaches or other allergy-related pain. But it might not be a great inclusion in your allergy meds. Some medications contain 650mg of acetaminophen in every dose. With a dosage frequency of every four hours, a day of allergy medications would come with nearly 4,000mg or a maximum dose of acetaminophen in one day.

If you’re just feeling a little bit scratchy in the throat, a maximum dose of painkillers isn’t necessary or beneficial. And remember—acetaminophen isn’t necessarily harmless.

The Best Medication for Cat Allergies: Our Top Picks Reviewed

Best Antihistamine Gel Cap: Allegra Allergy 24 Hour Gel Caps (Fexofenadine)

Allegra Allergy 24 Hour Gelcaps

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Fexofenadine is a second-generation antihistamine that minimizes the severity of sneezing, runny nose, itchiness, and fatigue.

Compared to sedating first-generation antihistamines, the drug has a limited ability to cross the blood-brain barrier. This makes it a relatively non-drowsy drug. The most common side effect among adult patients is a headache.

It’s sold under the brand name Allegra, but has been available as a generic drug since 2011.

This product is in a gel cap form, making it easy to swallow. It’s a fast-acting formula that starts producing results within an hour of dosage. Its effects last for up to 24 hours afterwards, giving you an entire day of protection.

It’s appropriate for people age 12 and over. Each gel cap offers 180mg fexofenadine.

What We Liked:

  • Fast-acting formula
  • 24 hour protection
  • Known for effectiveness
  • Soft gel caps are easy to swallow

What We Didn’t Like

  • Somewhat expensive

Runner Up: Zyrtec 24 Hour Allergy Relief Tablets

Zyrtec 24 Hour Allergy Relief Tablets

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As the number 1 allergist-recommended brand among OTC oral antihistamines, Zyrtec is an-ever popular, well-loved brand. Their 24-hour allergy relief tablets provide long-lasting, effective relief with minimal side effects.

The medication’s main ingredient is cetirizine HCl, a second-generation antihistamine that minimizes sneezing, runny nose, itching, allergic conjunctivitis, and hives. As a newer product, it’s long-lasting and non-drowsy. You’ll need to take just one tablet in the morning for all-day protection.

The product is approved for use in adults and children ages six and over. Each tablet provides 10mg cetirizine.

What We Liked

  • Effective
  • 24-hour allergy defense
  • One of the best-loved allergy medications on the market
  • Safe for adults and children aged 6 years and older

What We Didn’t Like

  • Zyrtec is expensive and some may prefer to opt for a generic version of this antihistamine

Best Budget Antihistamine Tablet: Basic Care Aller-Ease, Fexofenadine Hydrochloride Tablets

Basic Care All Day Allergy Cetirizine HCl Tablets

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Made with the same active ingredient—fexofenadine hydrochlodride—as our number one recommendation, this antihistamine from Amazon’s Basic Care brand is an economical, effective choice. Each tablet costs $0.21, making it less than half the price of Allegra.

Each tablet has 180mg Fexofenadine HCl, providing 24-hour relief of allergy symptoms like runny nose, sneezing, and itchy eyes, nose, and throat. This trusted antihistamine is non-drowsy and safe for people age 12 and over.

Customers say that this antihistamine is as effective as Allegra, saying that it’s one of the most trustworthy generic alternatives to the popular name brand product.

What We Liked

  • Provides consistent allergy relief without side effects
  • Significantly more affordable than the name brand alternative
  • 24 hour allergy defense

What We Didn’t Like

  • Round tablet format might not work for everyone

Best Nasal Steroid Spray: Nasacort Allergy 24 Hour (Triamcinolone)

Nasacort Allergy 24

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Nasal steroid sprays are generally the most effective allergy treatment on the market.

Triamcinolone is a synthetic glucocorticoid, which means that it bonds to glucocorticoid receptors in the body. Glucocorticoids are naturally present in the body and help to regulate immune function and inflammation. By introducing a synthetic version of these hormones, you can produce an enhanced anti-inflammatory effect.

This 24-hour spray from Nasacort relieves congestion, sneezing, and itchiness. It’s alcohol and scent free, so it’s unlikely to cause irritation.

It starts working on the first day and provides the maximum effect after a few days to one week of daily use.

Remember that nasal steroids are contraindicated for use in people with glaucoma, ulcers, or cataracts. You also should avoid this product if you’re using other steroid medications.

What We Liked

  • Highly effective in managing nasal symptoms
  • Easy to administer
  • Non-irritating and scent-free

What We Didn’t Like

  • Relatively slow-acting
  • Unsafe for certain groups

Best Liquid Medication for Children with Cat Allergies: Basic Care Children’s All Day Allergy Cetirizine HCl Oral Solution

Basic Care Children's All Day Allergy Cetirizine HCl Oral Solution

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This medication is made with cetirizine and is formulated for children. Each 5ml serving contains 5mg Cetirizine Hydrochloride.

The grape-flavored liquid solution is palatable and easy to administer. It’s dye-free and sugar-free. Instead of sugar, the formula uses sorbitol and sucralose as substitute sweeteners.

It’s a good generic product that you can find at a very low price on Amazon. The Amazon listing comes with a simple dosing tracker so that you can make sure that the dosing is just right.

Although it’s sold for children, it’s also appropriate for adults who prefer liquid medications.

What We Liked

  • Appropriate for children 2 years and older
  • Effective
  • Grape flavored liquid is easy to drink
  • 24 hour allergy control

What We Didn’t Like

  • Contains sucralose and sorbitol, which are controversial artificial sweeteners

Remember—allergy medications are just one part of your cat allergy treatment plan.

We mentioned at the beginning of the article that medications aren’t a complete solution. With a multifaceted approach, you can reduce your cat allergies to a manageable level. Here are a few steps to bring you closer to that goal.

Start with the allergens on your cat.

Remember that cat allergens are secreted in your cat’s skin, saliva, and urine. By removing those allergens from your cat’s body, you can cut back on the allergens in your environment. If possible, a non-allergic individual should handle these tasks.

Wash your cat, potentially using an allergen-blocking shampoo.

While washing with an ordinary shampoo or dish soap will help, an allergen blocking shampoo may be even better. There’s some evidence that allergen-blocking shampoos can neutralize dander. Just don’t bathe your cat more than once or twice a week. Any more could dry out their skin.

Minimize shedding.

While cat hair isn’t allergenic itself, it carries dander and saliva, both of which contain cat allergens. By brushing your cat and throwing away the hair, you’ll minimize the amount of hair and dander in your home.

Keep your cat’s skin healthy.

Unhealthy skin breaks and flakes and sprinkles through your house. By improving your cat’s skin and coat health, you can minimize the amount of allergenic dander in the area. Omega-3 fatty acid supplements and a stellar diet can keep your cat’s skin and coat supple and strong.

Reduce allergens in the environment.

At roughly 1/10th the size of a dust allergen, these microscopic particles become airborne and remain in the environment for up to 6 months after the cat is no longer in the area. Regular cleaning is a necessity for those with cat allergies. Here are a couple ways to make a big impact.

Also Read: Best Dust Free Cat Litter Guide

Use an air purifier.

Capture airborne allergens with an air purifier. Not all air purifiers are equal, but the best ones capture these microscopic particles and make a big difference for allergy sufferers.

Also Read: The Top 5 Best Air Purifiers for Pet Hair, Dander, Allergies, and Odor

Vacuum regularly.

A powerful Roomba vacuum removes cat hair and dander from carpet and upholstery. If you choose one with a HEPA filter and minimal exhaust, allergenic particles will remain trapped in the vacuum and won’t re-enter the environment.

Click here for our list of the best vacuums for pet hair.

About the author

Mallory Crusta is a writer and adventurecat enthusiast on a mission to make cats’ lives extraordinary. She’s one of the founders of Wildernesscat – a site for happy, healthy, and adventurous cats who are fueled by nature. Visit Wildernesscat for radically natural cat nutrition, home remedies, and lifestyle inspiration.

2 thoughts on “Best Medication for Cat Allergies

    1. Mallory CrustaMallory Crusta

      Hi Mary,

      Are you asking how much allergy medicine you should give a cat?

      It’s best to consult your veterinarian before giving your cat an antihistamine or other medication for allergies. Of the drugs available, cetirizine (the active ingredient in Zyrtec) is the safest and most widely used in veterinary practice. Dr. Shelley Knudsen, DVM of All Feline Hospital in Lincoln, Nebraska recommends “½ of a 10mg tablet (5mg) once daily.” If you want to take a safer route, consider salmon oil or fish oil. Fish oil is rich in omega-3 fatty acids, which can reduce allergy-caused inflammation without any known side effects.

      Hope this answers your question.

      – Mallory


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